Biologists at the University of California gave back the clock molecular stem cell infusion and managed to rejuvenate aged mice.

The study, announced in the journal Cell Reports and conducted by the University of California in conjunction with the Center for Regenerative Medicine at Massachusetts General Hospital, is a milestone in the understanding of the molecular mechanisms of aging and involves good news for treatments that are being developed on degenerative diseases of the elderly themselves.

What is the protein SIRT3

The study led to the discovery that the SIRT3 protein (class of proteins called sirtuins) is critical to the increased formation of new blood cells, demonstrating the reverse the decline of that age-related process and the function of stem cells old face stressful situations that occur over time. Recall that the function of adult stem cells is to repair and maintain the tissue that comes into function decline with time. In the case of hematopoietic stem cells (which are made ​​on the study), which are blood, is clearly visible this process, by its ability to completely reconstitute the blood system, which is necessary for which, for example, bone marrow transplantation is successful.


The main scientific study, Dr. Danica Chen, said: “We know that sirtuins regulate aging, but our study is really the first to demonstrate that they can reverse aging degeneration associated with, something I think very exciting “. Chen, an assistant professor of Nutritional Sciences and Toxicology, University of California, said: Studies have shown that even a single gene mutation can lead to longer life. The question is whether we can understand the process as well enough for us to really develop a molecular fountain of youth. Can we really reverse aging? This is something we are hoping to understand and follow.

Tests SIRT3 protein in the blood of mice

The study progressed with the gene detection SIRT3 protein in the blood of mice, some even have decreased. But the effect of SIRT3 was only in aged mice, aware that the young have their stem cells in good working order, and your stress levels are relatively low and oxidation. It is considered that at this stage of youth, the body produces antioxidant defenses against stress levels are not high.

Things change with age in this respect Dr. Chen said: “When we get older, our system does not work as well and generates oxidative stress that can not be removed, so levels build up. Under these conditions, our Normal antioxidant system can not take care of us, so that’s when we need to strengthen the system SIRT3 antioxidant. Yet SIRT3 levels also fall with age, so that over time, the system is overwhelmed. ”

Increased infusion of blood SIRT3 in mice

With these previous results, scientists SIRT3 elevated levels in the blood stem cells from older mice, and the test resulted rejuvenation blood stem cells older, generating an enhanced production cells blood system. However, the researchers involved are wary of talking about the prolongation of life and recognize that it is unclear whether the over-application of SIRT3 can do. In this regard, Chen: “An important objective of the field of aging is to use knowledge of the genetic regulation for the treatment of age-related diseases. Meanwhile, his colleague and director of research, Dr. Katharine Brown added that SIRT3 protein is likely to be used some in direction: “This is encouraging, because, ideally, you want a rejuvenation therapy in that can increase the expression of a protein without increasing the risk of diseases such as cancer.