Orlistat is a drug to achieve weight loss in obese or overweight. Adverse effects, contraindications, dosage, pregnancy and lactation.

Orlistat belongs to a class of drugs known as anti-obesity agents, gastrointestinal lipase inhibitors. Orlistat blocks the action of the lipase and thus prevents fat from the diet is absorbed and becomes adipose tissue. At the recommended dose, orlistat inhibits fat absorption by 30%.

Orlistat usage

This medication is indicated for long-term treatment, along with a low calorie diet moderate to obese patients (BMI greater than 30) or overweight (BMI 25 – 29.9), including those who have risk factors associated with obesity. The treatment leads to an improvement of the risk factors and disorders associated with obesity such as hypertension, type 2 diabetes, high cholesterol, or an excessive measure the waist and generally improving cardiovascular risk factors .


According to the doctor, Orlistat can also be used in combination with medications for diabetes to improve control of blood glucose on overweight or obese with type 2 diabetes whose blood sugar levels are not adequately controlled with diet, exercise and medications for diabetes (such as glyburide, insulin, metformin).

Doses and indications of orlistat

Orlistat is presented in 60 and 120 mg capsules. The dose is indicated by the doctor but is recommended for adults is 120 mg three times a day with each meal (breakfast, lunch and dinner) or up to 1 hour after the meal. If there is a skip in the food or the food contains no fat, the dose of orlistat should not be taken. The capsule is swallowed whole with a little water. Orlistat should be taken with a slightly low diet calorie containing not more than 30% of calories from fat, as recommended by your doctor, nutritionist or other health professional.

Contraindications and warnings of orlistat

Orlistat should not be used if you are allergic or hypersensitive to own medication or any other ingredients of the medicinal product or if you have cholesterol (a condition that stops the excretion of bile in the liver) or chronic absorption syndrome (food nutrients are not absorbed properly).

Check with your doctor

They may experience adverse side effects other than those listed. Consult your doctor, even for other questions that arise, as this article is general information and not intended to replace consultation with your health care professional or pharmacist.