Excessive fatigue, coupled with a diverse and variable symptoms, it could be a crippling disease of difficult diagnosis and treatment.

Chronic fatigue syndrome is a clinical picture characterized by symptoms that prevent a person who suffers lead a normal life. Generates a progressive disability in many cases not diagnosed with certainty due to the specificity and the subjectivity of its symptoms. In recent years, several researchers have focused on elucidating the causes and essential features of the picture, so as to give a defined framework that allows its early and correct diagnosis. It is believed with certainty that the syndrome would have a strong bio-psycho-social.


Possible causes neuroendocrine chronic fatigue syndrome

By Cleare A.J. Section of Neurobiology of Psychiatric Institute in London, the pathophysiological components of this syndrome remain unclear, but they have found strong evidence of the involvement of hypothalamic-pituitary-adrenal in its mechanism of production. This axis commands the hormonal responses of human and relates, among other things, to adapt to situations stress and / or changes (from problems of daily life to duels or surgery).

While no specific decisions have been found in the functioning of the shaft in people with this syndrome, they have been found inadequate response of the hormone cortisol (the main hormone of wakefulness and reaction to stress) and its liberation, the ACTH (adrenocorticotropin) to distressing or stressful situations considered.

Signs and symptoms of chronic fatigue syndrome

The researcher Ursini F, University of Catanzaro, Italy, defines chronic fatigue box as a syndrome characterized by a profound inability chronic (not acute, it is important to clarify), caused by extreme daytime sleepiness that is associated with a high diversity of physical symptoms seemingly unrelated to each other in many cases, the etiology or cause is unknown. Cleare Ursini matches in assessing the possible involvement of the hypothalamic-pituitary-adrenal production.

When the body wakes up after a night of rest, and even during sleep, is a close interplay between brain structures (hypothalamus-pituitary) and adrenal glands (Or adrenal glands located on these small kidneys, which produce and release the powerful vigil hormone is cortisol). A dysfunction in the balance of this axis alters many body functions. Each shaft structure frees a first substance which in turn causes the release of a second, which ultimately causes the release of cortisol. This system normally monitors and feeds back on itself, an increase in the last chain hormone (cortisol) inhibit the production of their liberators to compensate for its concentration in the body (otherwise its value continue to rise in blood and among other things descompensaria blood pressure rising).

When this “conversation” and interaction between components of the shaft is unbalanced,-and this can occur for various reasons bio-psycho-social dynamics that alter the normal and healthy life of an individual-the body’s responses to stress, mechanisms of arousal and sleep, and adaptation to physical and psychological demands of daily life, among other functions are affected.

A daily chronic fatigue, Disabling, could be installed, along with nighttime sleep disturbances as a result of hormonal imbalance caused by not adapting to the demands of life “imposed”, or changes the person wants to carry out even against obstacles that are insurmountable subjective analysis.

Chronic fatigue syndrome or myalgic encephalomyelitis: diagnostic criteria

In the U.S., among other places in the world, this syndrome is known as myalgic encephalomyelitis, Or condition involving brain inflammation associated with muscle aches. Both the U.S. and in England, reaffirmed the indispensable condition of getting a sufficiently severe and chronic fatigue, as to cause almost total loss of physical and social activities for a minimum period of six months, to be considered the diagnosis of the syndrome chronic fatigue. The Fibromyalgia is a condition that is often confused with chronic fatigue, and in several cases has come to be considered the same entity.

This primary disability must be added also at least four of the following symptoms to establish with certainty the diagnosis:

¤ Sleep disturbance (usually unrefreshing sleep, without rest or sleepiness during the day)
¤ Impaired concentration
¤ Muscle aches
¤ Joint pain
¤ Headaches
¤ Marked exacerbation of fatigue after strenuous exercise
¤ Sore throat
¤ Lymphadenopathy

Cases with clear organic bases should be excluded (severe depression, psychosis, etc..), As well as addictions to substances or unauthorized use anxiolytic drugs or similar prescription. However, no severe pathologies including melancholia and / or anxiety are associated with chronic fatigue syndrome.


Chronic fatigue syndrome or myalgic encephalomyelitis is a table full investigation of its causes and treatment, although it is considered that biological factors, psychological and social impact in their production. The hypothalamic-pituitary-adrenal would be deeply involved in the process.

The interaction of the nervous and endocrine systems in their actions linked to the processing of various psychological stress would cause a hormonal axis dysfunction that triggers an imbalance of energy day and night breaks, which as a consequence contribute to the chronicity and severity of this syndrome, the occurrence of various symptoms associated with fatigue, and difficulty in defining diagnostic and comprehensive treatment possible from the perspective of allopathic medicine.